HCID 178490822, compound → HCID 178490823, compound

Participants

Reaction Steps

6-Amino-3-(3-benzyloxy-4-methoxy-benzyl)-8-isopropyl-3H-purine hydrochloride (4.04 g, 9.2 mmole), in THF:methanol (1:1) (600 ml) was hydrogenated for 10 hours over 10% Pd-C (0.8 g) at room temperature and pressure. The catalyst was filtered off, the solvents removed in vacuo and the residue crystallized from acetone to give 6-amino-3-(3-hydroxy-4-methoxy-benzyl)-8-isopropyl-3H-purine hydrochloride (2.53 g, 78.8%), mp 125-130/185-195° C.

Provenance & Evidence