Pyridine → HCID 21998647, compound

Participants

Reaction Steps

To a well-stirred solution of 5-benzyloxycarbonyl-1,6-dihydro-2-methoxy-4-methoxymethyl-6-(3,4-difluorophenyl)pyrimidine (12 g, 29 mmol) and pyridine (10 mL) in CH2Cl2 (100 mL) was added powdered 4-nitrophenyl chloroformate (8.69 g, 43 mmol) at 0° C. The reaction mixture was stirred for 12 h at room temperature and the solvent was evaporated from the filtrate and the residue was purified by column chromatography (SiO2, dichloromethane/hexane, 20%-50%) to give the product as a foam (14.2 g, 86%).

Provenance & Evidence