(4-fluoro-1-methyl-1H-indol-3-yl)-oxo-acetyl chloride → 3-(4-Fluoro-1-methyl-1H-indol-3-yl)-4-(1-methyl-6-nitro-1H-indol-3-yl)-pyrrole-2,5-dione

HRID 1976726Notes

Reaction equation

HRID 1976726 reaction equation
[F:1][C:2]1[CH:10]=[CH:9][CH:8]=[C:7]2[C:3]=1[C:4]([C:12](=O)[C:13](Cl)=[O:14])=[CH:5][N:6]2[CH3:11].Cl.C([O:21][C:22](=[NH:37])[CH2:23][C:24]1[C:32]2[C:27](=[CH:28][C:29]([N+:33]([O-:35])=[O:34])=[CH:30][CH:31]=2)[N:26]([CH3:36])[CH:25]=1)(C)C>>[F:1][C:2]1[CH:10]=[CH:9][CH:8]=[C:7]2[C:3]=1[C:4]([C:12]1[C:13](=[O:14])[NH:37][C:22](=[O:21])[C:23]=1[C:24]1[C:32]3[C:27](=[CH:28][C:29]([N+:33]([O-:35])=[O:34])=[CH:30][CH:31]=3)[N:26]([CH3:36])[CH:25]=1)=[CH:5][N:6]2[CH3:11]

Participants

3

Reactant 2

HCID 21999028(4-fluoro-1-methyl-1H-indol-3-yl)-oxo-acetyl chlorideHCID 699446352-(1-Methyl-6-nitro-1H-indol-3-yl)acetimidic acid isopropyl ester hydrochloride

Product 1

HCID 155136773-(4-Fluoro-1-methyl-1H-indol-3-yl)-4-(1-methyl-6-nitro-1H-indol-3-yl)-pyrrole-2,5-dione

Procedure

3-(4-Fluoro-1-methyl-1H-indol-3-yl)-4-(1-methyl-6-nitro-1H-indol-3-yl)-pyrrole-2,5-dione was prepared from (4-fluoro-1-methyl-1H-indol-3-yl)-oxo-acetyl chloride and 2-(1-methyl-6-nitro-1H-indol-3-yl)-acetimidic acid isopropyl ester hydrochloride.

Sources & evidence

ORD record
ord-62aad09d4eaa488ba59d37f3d720d4e3
Source dataset
uspto-grants-2001_05
Patent number
US06228877B1

Reaction notes

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