(6-acetylamino-1-methyl-1H-indol-3-yl)-oxo-acetyl chloride → N-{1-Methyl-3-[4-(1-methyl-6-nitro-1H-indol-3-yl)-2,5-dioxo-2,5-dihydro-1H-pyrrol-3-yl]-1H-indol-3-yl}-acetamide

HRID 1976729Notes

Reaction equation

HRID 1976729 reaction equation
C(N[C:5]1[CH:13]=[C:12]2[C:8]([C:9]([C:15](=O)[C:16](Cl)=[O:17])=[CH:10][N:11]2[CH3:14])=[CH:7][CH:6]=1)(=O)C.Cl.C([O:24][C:25](=[NH:40])[CH2:26][C:27]1[C:35]2[C:30](=[CH:31][C:32]([N+:36]([O-:38])=[O:37])=[CH:33][CH:34]=2)[N:29]([CH3:39])[CH:28]=1)(C)C>>[CH3:14][N:11]1[C:12]2[C:8](=[CH:7][CH:6]=[CH:5][CH:13]=2)[C:9]([NH:40][C:25](=[O:24])[CH3:26])([C:15]2[C:16](=[O:17])[NH:24][C:25](=[O:40])[C:26]=2[C:27]2[C:35]3[C:30](=[CH:31][C:32]([N+:36]([O-:38])=[O:37])=[CH:33][CH:34]=3)[N:29]([CH3:39])[CH:28]=2)[CH2:10]1

Participants

3

Reactant 2

HCID 21999035(6-acetylamino-1-methyl-1H-indol-3-yl)-oxo-acetyl chlorideHCID 699446352-(1-Methyl-6-nitro-1H-indol-3-yl)acetimidic acid isopropyl ester hydrochloride

Product 1

HCID 21998999N-{1-Methyl-3-[4-(1-methyl-6-nitro-1H-indol-3-yl)-2,5-dioxo-2,5-dihydro-1H-pyrrol-3-yl]-1H-indol-3-yl}-acetamide

Procedure

ss) N-{1-Methyl-3-[4-(1-methyl-6-nitro-1H-indol-3-yl)-2,5-dioxo-2,5-dihydro-1H-pyrrol-3-yl]-1H-indol-3-yl}-acetamide was prepared from (6-acetylamino-1-methyl-1H-indol-3-yl)-oxo-acetyl chloride and 2-(1-methyl-6-nitro-1H-indol-3-yl)-acetimidic acid isopropyl ester hydrochloride.

Sources & evidence

ORD record
ord-5553b4bf8c644100aba1dd9f7b70e6f4
Source dataset
uspto-grants-2001_05
Patent number
US06228877B1

Reaction notes

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