3,4-Bis-(1-methyl-6-nitro-1H-indol-3-yl)-pyrrole-2,5-dione → HCID 21999014, compound

Participants

Reaction Steps

3,4-Bis-(1-methyl-6-nitro-1H-indol-3-yl)-pyrrole-2,5-dione (50 mg, 0.11 mmole), as prepared in Example 2 g, was dissolved in N,N-dimethylformamide (10 mL), a catalytic amount of activated Raney Nickel was added and the reaction was shaken on a Parr Hydro-genator at 45 psi. for 20 hr. The reaction mixture was filtered through a bed of celite with ethyl acetate and concentrated. The product was purified by recrystallization from acetone and hexane to give 3,4-bis-(1-methyl-6-amino-1H-indol-3-yl)-pyrrole-2,5-dione (35 mg).

Provenance & Evidence