Benzyl 1-methyl-oxindole-5-carboxylate → 2,3-Dihydro-1-methyl-2-oxo-1H-indole-5-carboxylic acid

Participants

Reaction Steps

A solution of Example 59A (1.2 g, 4.27 mmol) in ethyl acetate (30 mL) and methanol (20 mL) was treated with 10% Pd/C (200 mg), stirred under hydrogen (balloon) for 18 hours, filtered through diatomaceous earth (Celite®) with 9:1 dichloromethane/methanol solution rinses, and concentrated to provide 460 mg of the desired product.

Provenance & Evidence