HuagongsheHuagongshe Chemistry Print Report · For research reference only
Oxygen → 5-bromo-7-chloro-1H-indole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Oxygen | HCID 977 | — |
| Reactant | 5-Bromo-7-chloroindoline | HCID 16789164 | — |
| Catalyst | Salcomine | HCID 26517 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 5-bromo-7-chloro-1H-indole | HCID 10728194 | 88.3% |
Reaction Steps
A mixture of Example 65B (0.120 g, 0.55 mmol) and salcomine (0.022 g, 0.06 mmol) in methanol (30 mL) was treated with oxygen over 18 hours and concentrated. The concentrate was purified by flash column chromatography on silica gel to provide 0.112 g of the desired product. MS (ESI(+)) m/z 232 (M+2) and 248 (M+NH4)+;
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06228868B1 |
| Source dataset | uspto-grants-2001_05 |
| ORD ID | ord-b8bc82664f4b4f9c83a2081e443a777b |
| Source note | uspto-grants-2001_05 |