Ammonium Chloride → HCID 21998738, compound

Participants

Reaction Steps

A solution of 3-methyl-4-nitrophenyl trifluoromethanesulfonate (8.96 g, 31.4 mmol) in THF (200 mL) at 0° C. was treated dropwise with 1M allylmagnesium bromide in THF (110 mL 110 mmol), stirred for 2 hours, transferred into saturated NH4Cl (200 mL), and extracted with ethyl acetate (200 mL). The extract was dried (MgSO4), filtered, and concentrated. The concentrate was purified by flash column chromatography with 9:1 hexanes/ethyl acetate to provide 3.19 g of the desired product.

Provenance & Evidence