HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Anhydride → HCID 21998724, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Anhydride | HCID 7918 | — |
| Reactant | Sodium Bicarbonate | HCID 516892 | — |
| Reactant | Methyl 3-amino-4-(methylamino)benzoate | HCID 15586064 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 21998724 | HCID 21998724 | 74.7% |
Reaction Steps
A solution of Example 75A (1.80 g, 10.0 mmol) in dichloromethane (100 mL) was treated sequentially with acetic anhydride (3.06 g, 30.0 mmol) and 10% NaHCO3 (100 mL) and stirred for 30 minutes. The organic layer was separated, washed with brine (30 mL), dried (MgSO4), filtered, concentrated until solid precipitated, treated with diethyl ether, and filtered to provide 1.66 g of desired product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06228868B1 |
| Source dataset | uspto-grants-2001_05 |
| ORD ID | ord-11a4a04320d64420bb683d0d510368fa |
| Source note | uspto-grants-2001_05 |