HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cyclopropylamine → 3-Bromo-4-(cyclopropylamino)-benzonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cyclopropylamine | HCID 69828 | — |
| Reactant | 3-Bromo-4-fluorobenzonitrile | HCID 123579 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 3-Bromo-4-(cyclopropylamino)-benzonitrile | HCID 21998727 | 118.9% |
Reaction Steps
A solution of 3-bromo-4-fluorobenzonitrile (9.33 mmol) and cyclopropylamine (7.90 g, 136 mmol) in methanol (60 mL) was heated to 60° C. for 20 hours and concentrated. The concentrate was purified by flash column chromatography with 96:4 hexane/ethyl acetate to provide 2.63 g of the desired product. MS (ESI(+)) m/z 239 (M+H)+;
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06228868B1 |
| Source dataset | uspto-grants-2001_05 |
| ORD ID | ord-700ba7b8bd034fbcb97e708891bd9913 |
| Source note | uspto-grants-2001_05 |