HuagongsheHuagongshe Chemistry Print Report · For research reference only
Piperidine → L-Phenylalanine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Piperidine | HCID 8082 | — |
| Reactant | Fmoc-phenylalanine | HCID 978331 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | L-Phenylalanine | HCID 6140 | — |
Reaction Steps
Wash Fmoc-phenylalanine on Sasrin resin (1.00 g, 0.69 mmol) with DMF (20 mL×2). Add 20% piperidine in DMF (20 mL), agitate for 5 minutes, and drain the solvent. Repeat two times for 15 minutes. Wash the residue with DMF (20 mL×5) and then CH2Cl2 (20 mL×5). Dry the resin in a vacuum oven at 40° C. for 20 hours to give title resin.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06228985B1 |
| Source dataset | uspto-grants-2001_05 |
| ORD ID | ord-1767389372f14f198f7fedf045473930 |
| Source note | uspto-grants-2001_05 |