HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1976861Generated: October 25, 2026
Isopropanol → Propan-2-yl 1-oxo-1,3-dihydro-2-benzofuran-5-carboxylate
https://huagongshe.com/reaction/1976861
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Isopropanol | HCID 3776 | — |
| Reactant | Ethyl 1,3-dihydro-1-oxoisobenzofuran-5-carboxylate | HCID 90088 | — |
| Product | Propan-2-yl 1-oxo-1,3-dihydro-2-benzofuran-5-carboxylate | HCID 21999398 | — |
Reaction Steps
Method B): 5-Ethoxycarbonylphthalid (52 g, 0.25 mole) is suspended in 2-propanol (1000 mL). Ti(iPro)4 (38 g, 0.14 mole) is added and the mixture is refluxed for 3 hours. The reaction mixture is cooled to 0° C. and the crystals are filtered off and washed with cold 2-propanol (70 mL). Yield: 47 g, 85%. DSC onset 144° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US06229026B1 |
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| Source dataset | uspto-grants-2001_05 |
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| ORD ID | ord-26db2d4fb6a9445cbba1b2222de1fe3e |
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| Source note | uspto-grants-2001_05 |
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