HuagongsheHuagongshe Chemistry Print Report · For research reference only
Oxygen → Acetophenone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Oxygen | HCID 977 | — |
| Reactant | Propylene Oxide | HCID 6378 | — |
| Reactant | 1-Phenylethanol | HCID 7409 | — |
| Reactant | Propylene | HCID 8252 | — |
| Reactant | N-Hydroxyphthalimide | HCID 10665 | — |
| Catalyst | Cobalt diacetate | HCID 6277 | — |
| Solvent | Benzonitrile | HCID 7505 | — |
| Product | Acetophenone | HCID 7410 | 98% |
Reaction Steps
To a mixture of 1 mole of α-phenethyl alcohol, 0.1 mole of N-hydroxyphthalimide, 1 mmol of cobalt (II) acetate and 1 l of benzonitrile was added 1.5 moles of propylene, and the resultant mixture was stirred at 80° C. under oxygen atmosphere (oxygen: 1 atm) for 6 hours. Gas chromatographic analysis of products in a reaction mixture revealed that 0.92 mole of propylene oxide was formed, and that acetophenone (yield 98%: on α-phenethyl alcohol basis) was produced. The conversion rate from (x-phenethyl alcohol was 99%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06229023B1 |
| Source dataset | uspto-grants-2001_05 |
| ORD ID | ord-f26a89fe92bb47beb3b1f8d96b232338 |
| Source note | uspto-grants-2001_05 |