反应详情

温度

40 °C

Into 130 ml of methanol, 5.48 g (19 mmol) of 3-(2-nitro-benzo[d]phenyl)-2-methyl-2-propenoic acid ethyl ester were dissolved; and, with 23 ml of a 2-N aqueous sodium hydroxide solution being added thereto, the resulting mixture was stirred at 40° C. for one night. After the completion of the reaction was confirmed by TLC, the reaction liquid was concentrated under a reduced pressure. The pH of the concentrated product was adjusted to 1 with 1-N hydrochloric acid being added thereto, and the precipitated crystal was filtered out. Thus obtained crystal was washed with water and a small amount of methanol, and was dried, whereby 4.8 g of the aimed compound were obtained as a crystal (yield: 98%).

1. customthe reaction liquid
2. concentrationwas concentrated under a reduced pressure
3. additionadded
4. filtrationthe precipitated crystal was filtered out
5. washThus obtained crystal was washed with water
6. dry with materiala small amount of methanol, and was dried