HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 3-(2-Aminophenyl)-2-methyl-2-propenoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 3-(2-Amino-4,5-dimethoxyphenyl)-2-methyl-2-propenoic acid phenethyl amide | HCID 70214889 | — |
| Reactant | Ethyl 3-(2-aminophenyl)-2-methyl-2-propenate | HCID 70217004 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 3-(2-Aminophenyl)-2-methyl-2-propenoic acid | HCID 67245272 | — |
Reaction Steps
Into 10 ml of tetrahydrofuran (THF), 1.50 g (7.31 mmol) of (E) ethyl 3-(2-aminophenyl)-2-methyl-2-propenate were dissolved; and, with 10 ml of a 1-N aqueous sodium hydroxide solution being added thereto, the mixture was reacted at 40° C. for 4 hours. After the completion of the reaction was verified by TLC, the mixture was cooled with 10 ml of 1-N hydrochloric acid being added thereto. The precipitated crystal was filtered out, whereby 1.30 g of the aimed compound were obtained (yield: quantitative).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06229020B1 |
| Source dataset | uspto-grants-2001_05 |
| ORD ID | ord-711e3eb202ec49aa8e41da4803416979 |
| Source note | uspto-grants-2001_05 |