HCID 53992867, compound → HCID 21705592, compound

HRID 1976912Notes

Reaction equation

HRID 1976912 reaction equation
C([O:8][C:9]([C:11]1([N:17]([CH:35]=[CH:36][C:37]([O:39][CH2:40][CH3:41])=[O:38])[S:18]([C:21]2[CH:26]=[CH:25][C:24]([O:27][C:28]3[CH:33]=[CH:32][C:31]([F:34])=[CH:30][CH:29]=3)=[CH:23][CH:22]=2)(=[O:20])=[O:19])[CH2:16][CH2:15][O:14][CH2:13][CH2:12]1)=[O:10])C1C=CC=CC=1.[H][H]>C(O)C.O>[CH2:40]([O:39][C:37]([CH2:36][CH2:35][N:17]([S:18]([C:21]1[CH:26]=[CH:25][C:24]([O:27][C:28]2[CH:29]=[CH:30][C:31]([F:34])=[CH:32][CH:33]=2)=[CH:23][CH:22]=1)(=[O:20])=[O:19])[C:11]1([C:9]([OH:10])=[O:8])[CH2:12][CH2:13][O:14][CH2:15][CH2:16]1)=[O:38])[CH3:41]

Participants

5

Reactant 2

HCID 53992867HCID 53992867, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 21705592HCID 21705592, compound

Reagents, catalysts & solvents 2

HCID 962WaterCatalystHCID 702EthanolSolvent

Procedure

A solution of (4.4 mmol) of the product of step D in 25 mL of ethanol is treated with 2.5 g of 50% water wet 10% palladium on carbon catalyst and shaken under 53 psi of hydrogen for 21 hours. The catalyst is removed by filtration and washed with ethanol (4×25 mL). The filtrate and washings are combined and concentrated under vacuum to crude product.

Workup

  1. customThe catalyst is removed by filtration
  2. washwashed with ethanol (4×25 mL)
  3. concentrationconcentrated under vacuum to crude product

Sources & evidence

ORD record
ord-100130578bf140279bd6bd1762958f10
Source dataset
uspto-grants-2001_05
Patent number
US06229025B1

Reaction notes

Loading…