HCID 53750502, compound → HCID 21705576, compound

HRID 1976916Notes

Reaction equation

HRID 1976916 reaction equation
C([O:8][C:9]([C:11]1([N:19]([CH:37]=[CH:38][C:39]([O:41][CH2:42][CH3:43])=[O:40])[S:20]([C:23]2[CH:28]=[CH:27][C:26]([O:29][C:30]3[CH:35]=[CH:34][C:33]([F:36])=[CH:32][CH:31]=3)=[CH:25][CH:24]=2)(=[O:22])=[O:21])[CH2:17][CH:16]2[O:18][CH:13]([CH2:14][CH2:15]2)[CH2:12]1)=[O:10])C1C=CC=CC=1.[H][H]>C(O)C.O>[CH2:42]([O:41][C:39]([CH2:38][CH2:37][N:19]([S:20]([C:23]1[CH:24]=[CH:25][C:26]([O:29][C:30]2[CH:31]=[CH:32][C:33]([F:36])=[CH:34][CH:35]=2)=[CH:27][CH:28]=1)(=[O:22])=[O:21])[C:11]1([C:9]([OH:10])=[O:8])[CH2:17][CH:16]2[O:18][CH:13]([CH2:14][CH2:15]2)[CH2:12]1)=[O:40])[CH3:43]

Participants

5

Reactant 2

HCID 53750502HCID 53750502, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 21705576HCID 21705576, compound

Reagents, catalysts & solvents 2

HCID 962WaterCatalystHCID 702EthanolSolvent

Procedure

A solution of (4.4 mmol) of the product of step D in 25 mL of ethanol is treated with 2.5 g of 50% water wet 10% palladium on carbon catalyst and shaken under 53 psi of hydrogen for 48 hours. The catalyst is removed by filtration and washed with ethanol (4×25 mL). The filtrate and washings are combined and concentrated under vacuum to crude product.

Workup

  1. customThe catalyst is removed by filtration
  2. washwashed with ethanol (4×25 mL)
  3. concentrationconcentrated under vacuum to crude product

Sources & evidence

ORD record
ord-90fb92b0cc5645dd8d046c830bb896a4
Source dataset
uspto-grants-2001_05
Patent number
US06229025B1

Reaction notes

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