Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Dimethylamine | HCID 674 | — |
| Reactant | 1,2,4-Trifluoro-5-nitrobenzene | HCID 75012 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | HCID 21999572 | HCID 21999572 | — |
Reaction Steps
To a solution of 2,4,5-trifluoronitrobenzene (8.9 g, 50 mmol) in 100 mL ethanol is bubbled dimethylamine gas (6.8 g, 150 mmol). The solution is heated at 80° C. in a Parr pressure reactor for 6 hours. After evaporation of the solvent the product is chromatographed on silica gel/methylene chloride to give Compound 18.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US06229055B1 |
|---|
| Source dataset | uspto-grants-2001_05 |
|---|
| ORD ID | ord-5fa71ec05ee04ac9b7e39d919f93f157 |
|---|
| Source note | uspto-grants-2001_05 |
|---|
