2-Chloro-4-(methylsulfonyl)benzoic acid → HCID 57298083, compound

HRID 1976989Notes

Reaction equation

HRID 1976989 reaction equation
[CH3:1][O:2][C:3](=[O:24])[C@H:4]([CH2:6][C:7]1[CH:12]=[CH:11][C:10]([NH:13][C:14]([C:16]2[C:21]([Cl:22])=[CH:20][CH:19]=[CH:18][C:17]=2[Cl:23])=[O:15])=[CH:9][CH:8]=1)[NH2:5].[Cl:25][C:26]1[CH:34]=[C:33]([S:35]([CH3:38])(=[O:37])=[O:36])[CH:32]=[CH:31][C:27]=1[C:28](O)=[O:29]>>[CH3:1][O:2][C:3](=[O:24])[C@H:4]([CH2:6][C:7]1[CH:8]=[CH:9][C:10]([NH:13][C:14]([C:16]2[C:21]([Cl:22])=[CH:20][CH:19]=[CH:18][C:17]=2[Cl:23])=[O:15])=[CH:11][CH:12]=1)[NH:5][C:28]([C:27]1[CH:31]=[CH:32][C:33]([S:35]([CH3:38])(=[O:37])=[O:36])=[CH:34][C:26]=1[Cl:25])=[O:29]

Participants

3

Reactant 2

HCID 7358632-Chloro-4-(methylsulfonyl)benzoic acidHCID 233839334-(2,6-Dichlorobenzoylamino)-L-phenylalanine methyl ester

Product 1

HCID 57298083HCID 57298083, compoundYield 73%

Procedure

4-[[(2,6-Dichlorophenyl)carbonyl]amino]-N-[(2-chloro-4-methylsulfonylphenyl)carbonyl]-L-phenylalanine methyl ester was prepared in 73% yield from 4-[[(2,6-dichlorophenyl)carbonyl]amino]-L-phenylalanine methyl ester and 2-chloro-4-methylsulfonylbenzoic acid using the general procedure described in example 3. HR MS: Obs. mass, 583.0263. Calcd. mass, 583.0264 (M+H).

Sources & evidence

ORD record
ord-cba90bced6114e1a9947ada1de06f2c4
Source dataset
uspto-grants-2001_05
Patent number
US06229011B1

Reaction notes

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