2-Methanesulfonylbenzoic acid → HCID 53960380, compound

HRID 1976994Notes

Reaction equation

HRID 1976994 reaction equation
[CH3:1][O:2][C:3](=[O:24])[C@H:4]([CH2:6][C:7]1[CH:12]=[CH:11][C:10]([NH:13][C:14]([C:16]2[C:21]([Cl:22])=[CH:20][CH:19]=[CH:18][C:17]=2[Cl:23])=[O:15])=[CH:9][CH:8]=1)[NH2:5].[CH3:25][S:26]([C:29]1[CH:37]=[CH:36][CH:35]=[CH:34][C:30]=1[C:31](O)=[O:32])(=[O:28])=[O:27]>>[CH3:1][O:2][C:3](=[O:24])[C@H:4]([CH2:6][C:7]1[CH:8]=[CH:9][C:10]([NH:13][C:14]([C:16]2[C:21]([Cl:22])=[CH:20][CH:19]=[CH:18][C:17]=2[Cl:23])=[O:15])=[CH:11][CH:12]=1)[NH:5][C:31]([C:30]1[CH:34]=[CH:35][CH:36]=[CH:37][C:29]=1[S:26]([CH3:25])(=[O:28])=[O:27])=[O:32]

Participants

3

Reactant 2

HCID 2843422-Methanesulfonylbenzoic acidHCID 233839334-(2,6-Dichlorobenzoylamino)-L-phenylalanine methyl ester

Product 1

HCID 53960380HCID 53960380, compoundYield 99%

Procedure

4-[[(2,6-Dichlorophenyl)carbonyl]amino]-N-[(2-methylsulfonylphenyl)carbonyl]-L-phenylalanine methyl ester was prepared in 99% yield from 4-[[(2,6-dichlorophenyl)carbonyl]amino]-L-phenylalanine methyl ester and 2-methylsulfonylbenzoic acid using the general procedure described in example, LR MS: 548 (M+).

Sources & evidence

ORD record
ord-d0cd7934e5b54de2a3b4338a1fd829bc
Source dataset
uspto-grants-2001_05
Patent number
US06229011B1

Reaction notes

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