Hydrochloric Acid → HCID 178455746, compound

Participants

Reaction Steps

A mixture prepared by adding 3.3 g (16.5 mmol) of sodium benzenesulfinate dihydrate, 2.7 ml of 6N hydrochloric acid, and 25 ml of mixed solvent of toluene/ethanol (1/1) to 3.5 g (8.3 mmol) of the crude 4-(trans-4-(2-(4-vinylcyclohexyl)vinyl)cyclohexyl)-4′-butylbiphenyl was refluxed for 95 hours. Water in an amount of 50 ml was added to the reaction mixture, and the mixture was extracted with 100 ml of toluene, washed with water thrice, and dried over anhydrous magnesium sulfate. The solvent was distilled off under a reduced pressure, and the residue was subjected to silica gel column chromatography (eluent: toluene/heptane=1/9) to obtain 2.8 g of a crude (E)-4-(trans-4-(2-(trans-4-vinylcyclohexyl)vinyl)cyclohexyl)-4′-butylbiphenyl. This product was recrystallized from a mixed solvent of ethanol/ethyl acetate to obtain 0.7 g of the subjective compound.

Provenance & Evidence