HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → HCID 21997246, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Phenol | HCID 996 | — |
| Reactant | 2,5-Dichloropyridine | HCID 27685 | — |
| Reactant | (Octahydro-1H-pyrido[1,2-A]pyrazin-7-YL)methanol | HCID 12985539 | — |
| Product | HCID 21997246 | HCID 21997246 | — |
Reaction Steps
The title compound was prepared according to Example 15 using 2,5-dichloropyridine, (7RS,9aSR)-7-hydroxymethyl-2,3,4,6,7,8,9,9a-octahydro-1H-pyrido[1,2-a]pyrazine (U.S. Pat. No. 5,326,874), and phenol. mp (—HCl) 218-224° C. 13C NMR (base, CDCl3): δ27.0, 29.1, 36.4, 45.3, 50.9, 54.6, 58.8, 60.5, 70.9, 107.8, 114.5, 120.1, 120.7, 129.4, 137.1, 146.2, 157.6, 159.0. Anal. calcd for C20H24ClN3O C, 67.12; H, 6.76; N, 11.74; found: C, 67.22; H, 6.85; N, 11.49.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06231833B1 |
| Source dataset | uspto-grants-2001_05 |
| ORD ID | ord-2f32adaabb33454ea08b4a9bd70d6211 |
| Source note | uspto-grants-2001_05 |