HuagongsheHuagongshe Chemistry Print Report · For research reference only
2,5-Dichloropyridine → HCID 69433535, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2,5-Dichloropyridine | HCID 27685 | — |
| Reactant | 3,5-Difluorophenol | HCID 75928 | — |
| Reactant | HCID 22882696 | HCID 22882696 | — |
| Product | HCID 69433535 | HCID 69433535 | — |
Reaction Steps
A mixture of (7R,9aS)-N-BOC-7-hydroxymethyl-2,3,4,6,7,8,9,9a-octahydro-1H-pyrido[1,2-a]pyrazine (WO 93/25552) and 3,5-difluorophenol were coupled followed by N-BOC deprotection according to Preparation 9. The product from this reaction was coupled with 2,5-dichloropyridine according to Preparation 11 to give the title compound. mp (—HCl) 260-261° C. HRMS calcd for C20H22ClF2N3O: 393.1419, found: 393.1410.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06231833B1 |
| Source dataset | uspto-grants-2001_05 |
| ORD ID | ord-7fe2fc743f8b4ef4b5c2b36a725fb3ea |
| Source note | uspto-grants-2001_05 |