HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1977083Generated: October 26, 2026
Sodium Hydroxide → 1-Methyl-5-(methylthio)-1H-pyrazol-3-amine
https://huagongshe.com/reaction/1977083
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 3-Amino-1-methyl-5-methylsulfanyl-1H-pyrazole-4-carbonitrile | HCID 2819539 | — |
| Reactant | Monosodium phosphate | HCID 23672064 | — |
| Product | 1-Methyl-5-(methylthio)-1H-pyrazol-3-amine | HCID 54228438 | — |
Reaction Steps
5.55 g (33.0 mmol) of 3-amino-4-cyano-1-methyl-5-methylmercaptopyrazole are heated to the boil with 50 ml of 32% strength aqueous sodium hydroxide solution for 24 hours. The reaction mixture is cooled, made slightly acidic with sodium dihydrogen phosphate solution, heated at 50° C. for 8 hours and subsequently extracted with ethyl acetate. The organic phase is dried over sodium sulfate, concentrated and purified by column chromatography (silica gel, hexane/ethyl acetate).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US06232271B1 |
|---|
| Source dataset | uspto-grants-2001_05 |
|---|
| ORD ID | ord-df3bf41292254ced9e046234580ac082 |
|---|
| Source note | uspto-grants-2001_05 |
|---|
