Ethylene Glycol → HCID 15405497, compound

Participants

Reaction Steps

0.6 g (1.5 mmol) of 4-cyano-5-diethoxymethyl-1-(4-chloro-1-methyl-5-methylsulfonyl-3-pyrazolyl)pyrazole (Example B.2) and 0.5 ml of ethylene glycol together with 10 mg of p-toluenesulfonic acid are heated under reflux in 20 ml of toluene for 3 hours. Shaking with sodium bicarbonate and water, drying (sodium sulfate) and concentration using a rotary evaporator gives, in crystalline form, the desired product which can be further purified, if required, by recrystallization or silica gel column chromatography.

Provenance & Evidence