反应详情

A mixture of 4-pentafluoroethyl-benzonitrile (2.98 g, 13.5 mmol) and potassium hydroxide (3.03 g, 54.0 mmol) in water (40 mL) and ethanol (20 mL) was heated at reflux for 16 h. After cooling, the solution was partitioned between 1 M aq. hydrochloric acid solution and ethyl acetate. The organic layer was washed with brine, dried (MgSO4), and evaporated. Chromatography (SiO2, heptane-ethyl acetate gradient) produced the title compound (2.76 g, 85%). White solid, MS (ISP) 238.9 (M−H)−.

1. temperaturewas heated
2. temperatureat reflux for 16 h
3. temperatureAfter cooling
4. customthe solution was partitioned between 1 M aq. hydrochloric acid solution and ethyl acetate
5. washThe organic layer was washed with brine
6. dry with materialdried (MgSO4)
7. customevaporated