Hydrochloric Acid → HCID 9818358, compound

Participants

Reaction Conditions

Reaction Steps

N-(2-Cyanomethylsulfonyl-5-trifluoromethylphenyl)butyramide (0.41 g) in 0.5 M aqueous NaOH (5 ml) was stirred at room temperature for 2 h. The mixture was cooled to 0° C. and 1M HCl (4 ml) was added. After 30 min the precipitate was collected by filtration and dried to give 0.33 g (85%) of the title compound; mp 199.5-200.5° C.; El SP/MS: 316 (M+); 1H-NMR(CD3OD) δ (ppm): 8.16 (d, 1H); 7.73 (d+s, 2H); 4.88 (br, H2O+NH); (dd, 2H), 1.88 (sextet, 2H), 1.06 ppm (t, 3H).

Provenance & Evidence