Sodium Hydroxide → HCID 9816381, compound

HRID 1977121Notes

Reaction equation

[C:1]([CH2:3][S:4]([C:7]1[CH:12]=[C:11]([O:13][CH3:14])[CH:10]=[CH:9][C:8]=1[NH:15][C:16](=O)[CH3:17])(=[O:6])=[O:5])#[N:2].[OH-].[Na+]>>[CH3:17][C:16]1[NH:15][C:8]2[CH:9]=[CH:10][C:11]([O:13][CH3:14])=[CH:12][C:7]=2[S:4](=[O:6])(=[O:5])[C:3]=1[C:1]#[N:2]

Participants

Reactant 2

HCID 14798Sodium Hydroxide

HCID 21997626HCID 21997626, compound

Product 1

HCID 9816381HCID 9816381, compound

Procedure

Treatment of N-(2-cyanomethylsulfonyl-4-methoxyphenyl)acetamide with aqueous sodium hydroxide by a procedure similar to the procedure described in EXAMPLE 1 c) gave the title compound; mp 307-308° C. (from methanol), 1H-NMR (DMSO-d6), δ (ppm): 11.89 (br s, 1H, NH), 7.51-7.27 (m, 3H, Ar—H), 3.86 (s, 3H, CH3O), 2.44 (s, 3H, CH3).

Sources & evidence

ORD record: ord-ed32239d324a46579f02fcfb4e10d185
Source dataset: uspto-grants-2001_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06232310B1

Reaction notes

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