3,5-Di-tert-butyl-4-hydroxybenzaldehyde → 2,6-Dimethyl-4-(piperazin-1-ylmethyl)phenol

HRID 1977130Notes

Reaction equation

HRID 1977130 reaction equation
C[C:2]([C:5]1[CH:6]=[C:7]([CH2:16][N:17]2[CH2:22][CH2:21][NH:20][CH2:19][CH2:18]2)[CH:8]=[C:9]([C:12](C)(C)C)[C:10]=1[OH:11])(C)C.OC1C(C)=CC(C=O)=CC=1C.CC(C1C=C(C=C(C(C)(C)C)C=1O)C=O)(C)C>>[OH:11][C:10]1[C:5]([CH3:2])=[CH:6][C:7]([CH2:16][N:17]2[CH2:18][CH2:19][NH:20][CH2:21][CH2:22]2)=[CH:8][C:9]=1[CH3:12]

Participants

4

Reactant 3

HCID 732193,5-Di-tert-butyl-4-hydroxybenzaldehydeHCID 752223,5-Dimethyl-4-hydroxybenzaldehydeHCID 128958282,6-Di-tert-butyl-4-[(piperazin-1-yl)methyl]phenol

Product 1

HCID 35497312,6-Dimethyl-4-(piperazin-1-ylmethyl)phenol

Procedure

This was prepared using the general methodology described for the preparation of 1-(3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl)methylpiperazine except that 4-hydroxy-3,5-dimethylbenzaldehyde replaced the 3,5-bis(1,1-dimethylethyl)-4-hydroxybenzaldehyde.

Workup

  1. customThis was prepared

Sources & evidence

ORD record
ord-20289712777c46009ae067407c7fb515
Source dataset
uspto-grants-2001_05
Patent number
US06232314B1

Reaction notes

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