HCID 54219844, compound → HCID 22456975, compound

Participants

Reaction Steps

3-Fluoro-4-methoxy-α-methylcinnamic acid (49.5 g.; 0.236 mole), in 800 ml. methanol is hydrogenated at 43 lbs. pressure and room temperature until the theoretical uptake of hydrogen has occurred (24 min at 20° C., using 1.5 g. platinum oxide catalyst). The solution is filtered and then evaporated with warming to 60° to give 3-fluoro-4-methoxy-α-methyl dihydrocinnamic acid Rf 0.5 on silica-gel G with methylene chloride-methanol (9:1).

Provenance & Evidence