HCID 54174755, compound → HCID 22456979, compound

HRID 1977192Notes

Reaction equation

HRID 1977192 reaction equation
[F:1][C:2]1[CH:13]=[C:12]([F:14])[CH:11]=[CH:10][C:3]=1[CH:4]=[C:5]([CH3:9])[C:6]([OH:8])=[O:7].[H][H]>[Pt]=O.CO>[F:1][C:2]1[CH:13]=[C:12]([F:14])[CH:11]=[CH:10][C:3]=1[CH2:4][CH:5]([CH3:9])[C:6]([OH:8])=[O:7]

Participants

5

Reactant 2

HCID 54174755HCID 54174755, compoundHCID 178418361HCID 178418361, compound2×

Product 1

HCID 22456979HCID 22456979, compound

Reagents, catalysts & solvents 2

HCID 82844Platinum oxide (PtO)CatalystHCID 887MethanolSolvent

Procedure

In 800 ml. of methanol, 60 g. (0.3 mole) of 2,4-difluoro-α-methylcinnamic acid with 1.5 g. of platinum oxide catalyst is shaken under an initial pressure of 42 lbs. of hydrogen until one equivalent of hydrogen is absorbed. The reaction time is 30 minutes. The catalyst is removed by filtration and washed with methanol. The methanol, when evaporated off, leaves near colorless 2,4-difluoro-α-methyldihydrocinnamic acid as an oil which is used in the next step without further purification.

Workup

  1. customThe catalyst is removed by filtration
  2. washwashed with methanol
  3. customThe methanol, when evaporated off

Sources & evidence

ORD record
ord-da10567d220c4ae4a431480f09097551
Source dataset
uspto-grants-2001_05
Patent number
US06232312B1

Reaction notes

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