HCID 9805180, compound → HCID 9908433, compound

Participants

Reaction Steps

1-Benzyl-3-{3-[1-(4-fluoro-2-methoxyphenyl)piperidin-4-ylamino]propyl}-5-methyl-1H-pyrimidine-2,4-dione (Example 8) (100 mg, 0.2 mmol) was dissolved in a methanol solution of ammonium formate (0.1 M, 20 mL), treated with 10% palladium on carbon (100 mg) and the reaction heated to reflux for 24 h. The reaction mixture was filtered through a pad of celite, the filtrate concentrated and purified by pressurized silica gel chromatography (97.5:2:0.5 dichloromethane:methanol:ammonium hydroxide) to provide 3-{3-[1-(4-fluoro-2-methoxyphenyl)piperidin-4-ylamino]propyl}-5-methyl-1H-pyrimidine-2,4-dione. The hydrochloride salt was prepared according to conventional methods to provide a white solid.

Provenance & Evidence