Hydrochloric Acid → HCID 21997468, compound

Participants

Reaction Steps

A mixture of methyl 4-[5-[4-(6-methoxy-n-hexyloxy)-phenyl]-1,3,4-thiadiazol-2-yl]benzoate (179.6 g), sodium hydroxide (25.3 g), water (250 ml), methanol (1 L), and tetrahydrofuran (750 ml) was heated under refluxing for 1 hour then cooled to room temperature and poured into water (7 L). The pH of the stirred mixture was adjusted to 2.0 with 6N-hydrochloric acid and the precipitate collected by filtration, washed thoroughly with water, followed by acetonitrile, then dried under hi-vacuum at 50° C. to give 4-[5-[4-(6-methoxy-n-hexyloxy)phenyl]-1,3,4-thiadiazol-2-yl]benzoic acid (167 g) as a yellow powder.

Provenance & Evidence