1-Hydroxybenzotriazole → HCID 54195013, compound

Participants

Reaction Steps

A mixture of 4-[5-[4-(6-methoxy-n-hexyloxy)phenyl]-1,3,4-thiadiazole-2-yl]benzoic acid (50 g), 1-hydroxybenzotriazole (18 g) and 1-ethyl-3-(3′-dimethylaminopropyl)carbodiimide, hydrochloride (34.86 g) in methylene chloride (1 L) was stirred for 16 hours at room temperature then evaportated under reduced pressure and dried for 1 hour under hi-vacuum. Water (1 L) was added to the residue and the resulting precipitate collected by filtration, washed with water (1 L×5), acetonitrile (1L×5), isopropyl ether (250 ml×2), then dried under hi-vacuum to give 4-[5-[4-(6-methoxy-n-hexyloxy)phenyl]-1,3,4-thiadiazol-2-yl]benzoic acid benzotriazol-1-yl ester (56.92 g) as a yellow powder.

Provenance & Evidence