HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → HCID 21997548, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 2,6-Dimethylmorpholine, cis- | HCID 641500 | — |
| Reactant | HCID 21997455 | HCID 21997455 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | HCID 21997548 | HCID 21997548 | 45.8% |
Reaction Steps
A solution of methyl 4-[4′-(3-bromopropyoxy)phenyl]benzoate (1.5 g), potassium carbonate (1.2 g) and cis-2,6-dimethylmorpholine (990.6 mg) in N,N-dimethyformamide was stirred for 15 hours at room temperature, then diluted with ethyl acetate and washed with water (5x), dried over magnesium sulfate, evaporated, then purified by silica gel chromatography (20:1 dichloromethane-ethanol elution) to give methyl 4-[4′-[3-(2,6-dimethylmorpholino)propoxy]phenyl]benzoate (755 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06232290B1 |
| Source dataset | uspto-grants-2001_05 |
| ORD ID | ord-5436a3a7535b441e8e55c394fb6837f4 |
| Source note | uspto-grants-2001_05 |