HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1977289Generated: November 1, 2026
Methanol → Methyl 1-(4-aminophenyl)-1H-pyrazole-4-carboxylate
https://huagongshe.com/reaction/1977289
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | Ammonium Chloride | HCID 25517 | — |
| Reactant | HCID 11637370 | HCID 11637370 | — |
| Catalyst | Iron | HCID 23925 | — |
| Solvent | Water | HCID 962 | — |
| Product | Methyl 1-(4-aminophenyl)-1H-pyrazole-4-carboxylate | HCID 57210789 | 57.6% |
Reaction Steps
A mixture of 1-(4-nitrophenyl)-1H-pyrazol-4-carboxylic acid methyl ester (19.44 g), Fe powder, NH4Cl, methanol and H2O was heated for 30 minutes at 80° C. for 3 hours at 100° C. The reaction mixture was concentrated by evaporation, added into dichloromethane, and was filtered. The filtrate was extracted with water, dried over magnesium sulfate and concentrated by evaporation to give 1-(4-aminophenyl)-1H-pyrazol-4-carboxylic acid methyl ester (9.84 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US06232290B1 |
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| Source dataset | uspto-grants-2001_05 |
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| ORD ID | ord-04e3e676a7a24bac88703dc78c45d21a |
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| Source note | uspto-grants-2001_05 |
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