HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanol → HCID 20655630, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | Tetrahydrofuran | HCID 8028 | — |
| Reactant | Sodium borohydride | HCID 4311764 | — |
| Reactant | HCID 57286669 | HCID 57286669 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | HCID 20655630 | HCID 20655630 | 103.1% |
Reaction Steps
A mixture of 1-(4-formylphenyl)-1H-pyrazol-4-carboxylic acid methyl ester (1.00 g), methanol (10 ml) and tetrahydrofuran (25 ml) was treated with sodium borohydride at 0° C. After 15 minutes, the mixture was diluted with ethyl acetate and washed with water. The organic layer was dried over magnesium sulfate, filtered, and concentrated by evaporation to give 1-(4-hydroxymethylphenyl)-1H-pyrazol-4-carboxylic acid methyl ester (1.04 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06232290B1 |
| Source dataset | uspto-grants-2001_05 |
| ORD ID | ord-5cfc34d74a2247a8829e425dc30d7412 |
| Source note | uspto-grants-2001_05 |