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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1977290Generated: November 1, 2026

Methanol → HCID 20655630, compound

https://huagongshe.com/reaction/1977290

Reaction equation

Participants

RoleNameHCIDCharge
ReactantMethanolHCID 887—
ReactantTetrahydrofuranHCID 8028—
ReactantSodium borohydrideHCID 4311764—
ReactantHCID 57286669HCID 57286669—
SolventEthyl AcetateHCID 8857—
ProductHCID 20655630HCID 20655630103.1%

Reaction Steps

A mixture of 1-(4-formylphenyl)-1H-pyrazol-4-carboxylic acid methyl ester (1.00 g), methanol (10 ml) and tetrahydrofuran (25 ml) was treated with sodium borohydride at 0° C. After 15 minutes, the mixture was diluted with ethyl acetate and washed with water. The organic layer was dried over magnesium sulfate, filtered, and concentrated by evaporation to give 1-(4-hydroxymethylphenyl)-1H-pyrazol-4-carboxylic acid methyl ester (1.04 g).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06232290B1
Source datasetuspto-grants-2001_05
ORD IDord-5cfc34d74a2247a8829e425dc30d7412
Source noteuspto-grants-2001_05