3-Bromocyclohexene → HCID 54357020, compound

Participants

Reaction Steps

A solution of 4-(4-hydroxypiperidin-1-yl)benzoic acid ethyl ester (5.4 g), silver oxide (5.31 g) and 3-bromocyclohexene (3.24 ml) in tetrahydrofuran (52 ml) was stirred for 1 day at room temperature. The reaction mixture was filtered off, and the filtrate was concentrated by evaporation under reduced pressure. To the residue was added ethyl acetate, and the resulting precipitate was collected by filtration and dried. The residue was purified by silica gel chromatography (3:2 hexane-ethyl acetate elution) to give 4-[4-(2-cyclohexenyloxy)piperidin-1-yl]benzoic acid ethyl ester (3.84 g).

Provenance & Evidence