Water → HCID 135815285, compound

HRID 1977294Notes

Reaction equation

HRID 1977294 reaction equation
FC(F)(F)C(O)=O.C([O:10][C:11](=[O:34])[C:12]1[CH:17]=[CH:16][C:15]([C:18]2[N:19]=[C:20]3[N:24]([CH:25]=2)[N:23]=[C:22]([C:26]2[CH:31]=[CH:30][C:29]([O:32]C)=[CH:28][CH:27]=2)[S:21]3)=[CH:14][CH:13]=1)C.O>ClCCl>[OH:32][C:29]1[CH:30]=[CH:31][C:26]([C:22]2[S:21][C:20]3=[N:19][C:18]([C:15]4[CH:16]=[CH:17][C:12]([C:11]([OH:34])=[O:10])=[CH:13][CH:14]=4)=[CH:25][N:24]3[N:23]=2)=[CH:27][CH:28]=1

Participants

4

Reactant 2

HCID 962WaterHCID 70055559HCID 70055559, compound

Product 1

HCID 135815285HCID 135815285, compoundYield 130.6%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a suspension of 4-[2-(4-methoxyphenyl)imidazo[2,1-b][1,3,4]thiadiazol-6-yl]benzoic acid ethyl ester trifluoroacetic acid salt (1.0 g) in dichloromethane (10 ml) was added borone tribromide (1.0M solution in dichloromethane) (8.0 ml) at 0° C. and the mixture was stirred at ambient temperature for 1 week. The reaction mixture was pulverized with cold water. The precipitate was collected by filtration and dried to give 4-[2-(4-hydroxyphenyl)imidazo[2,1-b][1,3,4]thiadiazol-6-yl]benzoic acid (893 mg).

Workup

  1. filtrationThe precipitate was collected by filtration
  2. customdried

Sources & evidence

ORD record
ord-d0a827d0a59f4805b46c7c2ef5c74f30
Source dataset
uspto-grants-2001_05
Patent number
US06232290B1

Reaction notes

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