Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Acetic Acid | HCID 176 | — |
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Water | HCID 962 | — |
| Reactant | HCID 21997487 | HCID 21997487 | — |
| Product | HCID 21997527 | HCID 21997527 | — |
Reaction Steps
To a solution of 4-[4-[4-(4-cyclohexylphenyl)piperazin-1-yl]piperidin-1-yl]benzonitrile (1.95 g) in acetic acid (10 ml) was added concentrated hydrogen chloride (20 ml) and the mixture was stirred at 120° C. for 10 hours. The reaction mixture was added to water and the resulting precipitate was collected by filtration to give 4-[4-[4-(4-cyclohexylphenyl)piperazin-1-yl]piperidin-1-yl]benzoic acid (959 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US06232290B1 |
|---|
| Source dataset | uspto-grants-2001_05 |
|---|
| ORD ID | ord-c2f37360f91f44e48584c612d0e3f474 |
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| Source note | uspto-grants-2001_05 |
|---|
