Ammonia → 2-Methyl-3-hydroxy-4-pyridone

HRID 1977320Notes

Reaction equation

HRID 1977320 reaction equation
[NH3:1].[CH3:2][C:3]1O[CH:8]=[CH:7][C:5](=[O:6])[C:4]=1[OH:10]>>[CH3:2][C:3]1[CH:4]([OH:10])[C:5](=[O:6])[CH:7]=[CH:8][N:1]=1

Participants

3

Reactant 2

HCID 222AmmoniaHCID 8369Maltol

Product 1

HCID 666058152-Methyl-3-hydroxy-4-pyridone

Procedure

An ammonia solution is added to a solution of maltol dissolved in hot distilled water. The pH of this solution is adjusted to 9.8 by the addition of HCl solution. The mixture is kept under reflux overnight and then decolorized with activated charcoal. The solvent is removed under reduced pressure. The white product is obtained upon recrystallization from hot water.

Workup

  1. dissolutiondissolved
  2. distillationin hot distilled water
  3. additionThe pH of this solution is adjusted to 9.8 by the addition of HCl solution
  4. temperatureunder reflux overnight
  5. customThe solvent is removed under reduced pressure
  6. customThe white product is obtained upon recrystallization from hot water

Sources & evidence

ORD record
ord-916c1935482e428db0ef6ba3196c1c4a
Source dataset
uspto-grants-2001_05
Patent number
US06232340B1

Reaction notes

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