HuagongsheHuagongshe Chemistry Print Report · For research reference only
Kojic Acid → 5-Hydroxy-2-hydroxymethyl-1-methylpyrid-4-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Kojic Acid | HCID 3840 | — |
| Reactant | Methylamine | HCID 6329 | — |
| Solvent | Water | HCID 962 | — |
| Product | 5-Hydroxy-2-hydroxymethyl-1-methylpyrid-4-one | HCID 129682 | — |
Reaction Steps
A solution of 40% methylamine in water is added to a solution of kojic acid dissolved in hot distilled water. The pH of this solution is adjusted to 9.8 by the addition of HCl solution. The mixture is kept under reflux overnight and then decolorized with activated charcoal. The solvent is removed under reduced pressure. The white product is obtained upon recrystallization from hot water.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06232340B1 |
| Source dataset | uspto-grants-2001_05 |
| ORD ID | ord-6bd84b0b631b458cab6b84e28a00ecd3 |
| Source note | uspto-grants-2001_05 |