HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 5-(3,4-Dichlorobenzyl-carbamoyl)-thiophene-2-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 5-(3,4-Dichlorobenzyl-carbamoyl)-thiophene-2-carboxylic acid ethyl ester | HCID 22986153 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 5-(3,4-Dichlorobenzyl-carbamoyl)-thiophene-2-carboxylic acid | HCID 18617115 | 83% |
Reaction Steps
Aqueous 1M sodium hydroxide (16.3 mL; 16.3 mmole) was added to a stirring, solution of (12(a)) (1.17g; 3.3 mmole) in ethanol (70 mL). The reaction mixture was and adjusted to pH 2 by addition of 2M hydrochloric acid. The filtered solid was washed with water and dried in vacuo to give 5-(3,4-dichlorobenzyl-carbamoyl)-thiophene-2-carboxylic acid (12(b)) as a white solid (83%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06232338B1 |
| Source dataset | uspto-grants-2001_05 |
| ORD ID | ord-53974b4af3164fd9beb6868f59391c22 |
| Source note | uspto-grants-2001_05 |