HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzenemethanamine, 3,4-dichloro- → 5(3,4-Dichlorobenzylcarbamoyl)-pyridine-2-carboxylic acid methyl-ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzenemethanamine, 3,4-dichloro- | HCID 1608 | — |
| Reactant | 5-Chlorocarbonyl-pyridine-2-carboxylic acid methyl ester | HCID 15121177 | — |
| Reactant | 5-(3,4-Dichlorobenzyl-carbamoyl)-thiophene-2-carboxylic acid ethyl ester | HCID 22986153 | — |
| Reactant | 5-[N-(3,4-dichlorobenzyl)carbamoyl]-N-((2S,4S)-1-allyloxycarbonyl-4-sulfanylpyrrolidin-2-yl-methyl)pyridine-2-carboxamide | HCID 57304912 | — |
| Product | 5(3,4-Dichlorobenzylcarbamoyl)-pyridine-2-carboxylic acid methyl-ester | HCID 22986192 | 61% |
Reaction Steps
Starting material (13(e)) was prepared as follows, 5-chlorocarbonyl-pyridine-2-carboxylic acid methyl ester was reacted with 3,4-dichlorobenzylamine analogously with preparation of compound (12(a)) in Example 12 to obtain 5(3,4-dichlorobenzylcarbamoyl)-pyridine-2-carboxylic acid methyl-ester (13(a)) as a cream solid (61%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06232338B1 |
| Source dataset | uspto-grants-2001_05 |
| ORD ID | ord-6b1eb8a3dac4419e86d66f58bdd7d168 |
| Source note | uspto-grants-2001_05 |