反应详情

A mixture of ethyl 3-amino-2-[(2′-cyanobiphenyl-4-yl)-methyl]aminobenzoate (5.6 g) and sodium O-ethyl dithiocarbonate (7.3 g) in ethanol (50 ml) was heated for 8 hours under reflux. The reaction mixture was concentrated and the residue was dissolved in water. The solution was adjusted to pH 3-4 with hydrochloric acid. Precipitating crystals were collected by filtration, followed by recrystallization from ethanol to afford yellow crystals (5.0 g, 80%), m.p. 225-227° C.

1. temperaturewas heated for 8 hours
2. temperatureunder reflux
3. concentrationThe reaction mixture was concentrated
4. dissolutionthe residue was dissolved in water
5. customPrecipitating crystals
6. filtrationwere collected by filtration
7. customfollowed by recrystallization from ethanol