HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → 4-(4-chlorophenoxy)-N-methylthieno[2,3-c]pyridine-2-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Methylamine | HCID 6329 | — |
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | Methyl 4-(4-chlorophenoxy)thieno[2,3-c]pyridine-2-carboxylate | HCID 10892544 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 4-(4-chlorophenoxy)-N-methylthieno[2,3-c]pyridine-2-carboxamide | HCID 9883504 | — |
Reaction Steps
A solution of Example 61A (100 mg, 0.3135 mmol) and methylamine (2M solution in THF, 0.467 mL, 0.941 mmol) in THF (2 mL) at 0° C. was treated with NaH (12 mg, 0.47 mmol), stirred at room temperature for 1 hour, treated with water (0.1 mL), and concentrated. The residue was purified by flash chromatography on silica gel with 20% acetone/hexane to provide the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06232320B1 |
| Source dataset | uspto-grants-2001_05 |
| ORD ID | ord-b88142d0120348c58856f3009b114209 |
| Source note | uspto-grants-2001_05 |