HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → HCID 21998069, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Sodium Fluoride | HCID 5235 | — |
| Reactant | Hydrofluoric Acid | HCID 14917 | — |
| Reactant | HCID 21998068 | HCID 21998068 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 21998069 | HCID 21998069 | 96% |
Reaction Steps
N-[3,5-di-(4-(tert-butyldimethylsilyloxy)phenoxycarbonyl)phenyl]maleimide (35 g 0.052 mole) was dissolved in THF (500 ml). Hydrogen fluoride (2.5 M, 70 ml), sodium fluoride (3 g) and water (280 ml) were added. The reaction mixture was stirred overnight and most of the solvent was removed. Filtration of the product over a silica bed and concentration in vacuo afforded N-[3,5-di-(4-hydroxyphenoxycarbonyl)phenyl]maleimide (22.2 g, 96%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06232430B1 |
| Source dataset | uspto-grants-2001_05 |
| ORD ID | ord-0523a097ce0e440fb0bacd741529896d |
| Source note | uspto-grants-2001_05 |