HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → HCID 53857759, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | Benzenesulfonic acid, 3-nitro-, (2S)-2-oxiranylmethyl ester | HCID 146490 | — |
| Reactant | 1-benzyl-1H-pyrazol-4-ol | HCID 642218 | — |
| Product | HCID 53857759 | HCID 53857759 | 73.1% |
Reaction Steps
1-Benzyl-4-hydroxypyrazole (2 g, 11.5 mmol), potassium carbonate(3.2 g, 23 mmol), and (2s)-glycidyl-3-nitrobenzenesulfonate (2.98 g, 11.5 mmol) were slurried in actone (300 ml) at reflux for 17 hours. The acetone was removed in vacuo, the residue extracted from brine with chloroform, and dried over sodium sulfate. The solvent was removed again and the residue purified by column chromatography (silica gel, chloroform→1% methanol/chloroform) to yield product (1.8 g, 68%). MS, NMR.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06232337B1 |
| Source dataset | uspto-grants-2001_05 |
| ORD ID | ord-56d2d6921b5a497f9497609e5dabc569 |
| Source note | uspto-grants-2001_05 |