HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1977496Generated: November 2, 2026
Water → 1H-Isoindole-1,3(2H)-dione, 2-ethenyl-
https://huagongshe.com/reaction/1977496
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | 1H-Isoindole-1,3(2H)-dione, 2-(2-bromoethyl)- | HCID 11325 | — |
| Reactant | 1,8-Diazabicyclo(5.4.0)undec-7-ene | HCID 81184 | — |
| Solvent | Dimethylacetamide | HCID 31374 | — |
| Product | 1H-Isoindole-1,3(2H)-dione, 2-ethenyl- | HCID 77035 | — |
Reaction Steps
Over a period of 2 hours, 2.3 g of 1,8-diazabicyclo-[5.4.0]-undec-7-ene were added dropwise to a solution of 3.5 kg of N-(2-bromoethyl)phthalimide in 9.6 l of N,N-dimethylacetamide. During the addition, the temperature increased to 50° C. After the addition had ended, stirring was continued for 17 hours. The batch was poured into 29 l of water and filtered, and the filtration residue was dried at from 30 to 40° C. This gave 1.95 kg of product (=82% of theory) of melting point 79-80° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US06232475B1 |
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| Source dataset | uspto-grants-2001_05 |
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| ORD ID | ord-4dc3406cb13645798881eee19fa35b35 |
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| Source note | uspto-grants-2001_05 |
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