HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tetrahydrofuran → 2-(4-Chloro-3-trifluoromethyl-phenyl)-ethylamine hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tetrahydrofuran | HCID 8028 | — |
| Reactant | 2-(4-Chloro-3-(trifluoromethyl)phenyl)acetonitrile | HCID 5004685 | — |
| Reactant | 2-(3-Fluoro-5-trifluoromethyl-phenyl)-ethylamine hydrochloride | HCID 68563540 | — |
| Product | 2-(4-Chloro-3-trifluoromethyl-phenyl)-ethylamine hydrochloride | HCID 68560752 | — |
Reaction Steps
The title compound was synthesized in analogy to 2-(3-fluoro-5-trifluoromethyl-phenyl)-ethylamine hydrochloride (described in example S1-B) from 3.188 g of crude (4-chloro-3-trifluoromethyl-phenyl)-acetonitrile (14.5 mmol) and 76 ml of a 1M borane-THF complex solution in THF (76 mmol). The product was obtained as a white solid (1.52 g, 40%). MS (ISP) 224.1 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07745477B2 |
| Source dataset | uspto-grants-2010_06 |
| ORD ID | ord-d30c30e4a818477492ac9f355a673a49 |
| Source note | uspto-grants-2010_06 |